Nanotechnology

This paper describes a method to gauge the stiffness of nanosized liposomes – a nanoscale vesicle – using a custom-made recapture …

Enveloped viruses fuse with cells to transfer their genetic materials and infect the host cell. Fusion requires deformation of both …

This paper describes a general approach for transferring clean single-layer graphene onto silicon nitride nanopore devices and the use …

Solid-state nanopores have been widely used in the past for single-particle analysis of nanoparticles, liposomes, exosomes and viruses. …

This thesis lays the groundwork to develop novel enabling technologies based on nanopore resistive pulse sensing for characterization of vesicles’ elastic properties at nanoscale. Our data suggests that such platform can offer significant advantages over current state-of-the-art systems particularly in terms of throughput, costs and operability.

Solid-state nanopores have gained much attention as a bioanalytical platform. By virtue of their tunable nanoscale dimensions, nanopore …

Membrane deformation of nano-vesicles is crucial in many cellular processes such as virus entry into the host cell, membrane fusion, …

This paper describes microparticle and bacterial translocation studies using low aspect ratio solid-state micropores. Micropores, 5 μm …

In this project I made fluorescent gold quantum dots otheriwse known as gold nanodots to label Human Immunodeficiency Virus (HIV) entry inhibitors and visualize their interactions with HIV envelope protein. Using amino acids, proteins or alkyl thiols as capping agent, nanodots of various size and optical properties were synthesized. The nanodots were then conjugated to novel HIV entry-inhibitors of the peptide triazole family using EDC-NHS or SMCC chemistry. The peptide-nanodot conjuagte was then used to image and study interactions with cells that expressed HIV envelope proteins.

Layered double hydroxides (LDHs), well known as anionic or hydrotalcite-like clays consist of positively charged layers and …